EXCIPIENT IMPACT ON FENOFIBRATE EQUILIBRIUM SOLUBILITY IN FASTED AND FED SIMULATED INTESTINAL FLUIDS ASSESSED USING A DESIGN OF EXPERIMENT PROTOCOL

Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol

Solubility Hinges is a critical parameter controlling drug absorption after oral administration.For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues.This study has applied a small scale design of experi

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Seed dormancy loss from dry after-ripening is associated with increasing gibberellin hormone levels in Arabidopsis thaliana

IntroductionThe seeds of many plants are dormant and unable to germinate at maturity, but gain HONEY LIP BALM the ability to germinate through after-ripening during dry storage.The hormone abscisic acid (ABA) stimulates seed dormancy, whereas gibberellin A (GA) stimulates dormancy loss and germination.MethodsTo determine whether dry after-ripening

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Insights in the development in the pathogenesis of melasma

Folding Chair Cover The pathogenesis of melasma is complicated.Genetic predisposition, female sex hormone and photoaging play predominant roles in melasma.While the current research in this field has focused on the effects of female sex hormone and ultraviolet on the melanogenesis, melanin transportation and distribution through paracrine regulatio

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Illusory Rotation of a Spoked Wheel

A disk was Foley Catheters divided into 16 stationary sectors of different grey levels that stepped around clockwise.When thin stationary spokes of constant mid-grey separated the sectors, the spokes showed robust and striking counterclockwise apparent motion, and when stopped, they gave a brisk clockwise motion aftereffect.The spokes had to match

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